[Improvement of skin moisture and skin texture with urea therapy]

Hautarzt. 1989;40 Suppl 9:67-70.
[Article in German]


A significant increase in skin moisture and an improvement in skin smoothness after application of a urea-containing cream was noticed in a large number of volunteers with healthy skin and in neurodermitis patients compared with untreated skin and with vehicle. The effect was shown after one application (short-term test) as well as after repeated application (long-term test). Regular application of preparation containing urea increases the moisture of a the skin and improves the skin's smoothness compared with its previous condition, with untreated skin, and with placebo preparations.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • English Abstract

MeSH terms

  • Adult
  • Body Water / metabolism*
  • Dermatologic Agents / administration & dosage*
  • Female
  • Humans
  • Male
  • Neurodermatitis / drug therapy*
  • Ointments
  • Skin / drug effects*
  • Urea / administration & dosage*


  • Dermatologic Agents
  • Ointments
  • Urea