[Salicylic acid and urea--possible modification of the keratolytic effect of salicylic acid by urea]

Hautarzt. 1989;40 Suppl 9:71-3.
[Article in German]


The keratolytic effect of salicylic acid was measured with a colorimeter after staining the outer layers of the stratum corneum with silver nitrate. Salicylic acid was used in a concentration of 5% or 10% in vaseline or of 5% in an improved vehicle. The results of two experiments showed that improvement of the vehicle increased the keratolytic effect of salicylic acid and that urea played a major role in this improvement.

Publication types

  • English Abstract

MeSH terms

  • Dermatologic Agents / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Humans
  • Keratolytic Agents / pharmacology*
  • Skin / drug effects*
  • Skin Pigmentation / drug effects
  • Urea / pharmacology*


  • Dermatologic Agents
  • Keratolytic Agents
  • Urea