We introduce a novel concept for an optical waveguide called a strip-loaded slot waveguide. It allows an extraordinary confinement of the field in a waveguide with an extremely tiny (vertical) cross section. Unlike conventional slot waveguides, the proposed configuration has potential for very low propagation losses. Its operation is demonstrated at telecommunication wavelengths and, in addition, it is fabricated by means of mass production compatible techniques: atomic layer deposition and nanoimprint replication. The possibility to fabricate the proposed structure with such low-cost techniques opens a new path for a variety of nanophotonics applications.