Beyond Pressure Gradients: The Effects of Intervention on Heart Power in Aortic Coarctation

PLoS One. 2017 Jan 12;12(1):e0168487. doi: 10.1371/journal.pone.0168487. eCollection 2017.

Abstract

Background: In aortic coarctation, current guidelines recommend reducing pressure gradients that exceed given thresholds. From a physiological standpoint this should ideally improve the energy expenditure of the heart and thus prevent long term organ damage.

Objectives: The aim was to assess the effects of interventional treatment on external and internal heart power (EHP, IHP) in patients with aortic coarctation and to explore the correlation of these parameters to pressure gradients obtained from heart catheterization.

Methods: In a collective of 52 patients with aortic coarctation 25 patients received stenting and/or balloon angioplasty, and 20 patients underwent MRI before and after an interventional treatment procedure. EHP and IHP were computed based on catheterization and MRI measurements. Along with the power efficiency these were combined in a cardiac energy profile.

Results: By intervention, the catheter gradient was significantly reduced from 21.8±9.4 to 6.2±6.1mmHg (p<0.001). IHP was significantly reduced after intervention, from 8.03±5.2 to 4.37±2.13W (p < 0.001). EHP was 1.1±0.3 W before and 1.0±0.3W after intervention, p = 0.044. In patients initially presenting with IHP above 5W intervention resulted in a significant reduction in IHP from 10.99±4.74 W to 4.94±2.45W (p<0.001), and a subsequent increase in power efficiency from 14 to 26% (p = 0.005). No significant changes in IHP, EHP or power efficiency were observed in patients initially presenting with IHP < 5W.

Conclusion: It was demonstrated that interventional treatment of coarctation resulted in a decrease in IHP. Pressure gradients, as the most widespread clinical parameters in coarctation, did not show any correlation to changes in EHP or IHP. This raises the question of whether they should be the main focus in coarctation interventions. Only patients with high IHP of above 5W showed improvement in IHP and power efficiency after the treatment procedure.

Trial registration: clinicaltrials.gov NCT02591940.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aortic Coarctation* / physiopathology
  • Aortic Coarctation* / surgery
  • Blood Pressure*
  • Cardiac Catheterization*
  • Child
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Contraction*
  • Myocardium*

Associated data

  • ClinicalTrials.gov/NCT02591940

Grant support

This study was partially funded by the European Commission under the ICT Program (Grant Agreement: 611232, Brussels, Belgium) and by the German Research Foundation (Grant GO1067/6-1-KU1329/10-1, Berlin, Germany).