Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review

Int J Biol Macromol. 2017 Apr:97:228-237. doi: 10.1016/j.ijbiomac.2017.01.040. Epub 2017 Jan 10.


Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging. The purpose of the present review is to provide systematically reorganized information on extraction and purification, structure characteristics, biological activities, and industrial applications of H. erinaceus polysaccharides to support their therapeutic potentials and sanitarian functions.

Keywords: Hericium erinaceus; Industrial applications; Polysaccharides.

Publication types

  • Review

MeSH terms

  • Agaricales / chemistry*
  • Agaricales / growth & development
  • Agaricales / metabolism
  • Animals
  • Culture Techniques
  • Humans
  • Industry*
  • Polysaccharides / biosynthesis
  • Polysaccharides / chemistry*
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*


  • Polysaccharides