Miniaturized and integrated whole cell living bacterial sensors in field applicable autonomous devices

Curr Opin Biotechnol. 2017 Jun;45:24-33. doi: 10.1016/j.copbio.2016.11.023. Epub 2017 Jan 11.

Abstract

Live-cell based bioreporters are increasingly being deployed in microstructures, which facilitates their handling and permits the development of instruments that could perform autonomous environmental monitoring. Here we review recent developments of on-chip integration of live-cell bioreporters, the coupling of their reporter signal to the devices, their longer term preservation and multi-analyte capacity. We show examples of instruments that have attempted to fully integrate bioreporters as their sensing elements.

Publication types

  • Review

MeSH terms

  • Bacteria* / classification
  • Bacteria* / genetics
  • Biosensing Techniques
  • Environmental Monitoring*
  • Genes, Reporter