Could post-weaning dietary chia seed mitigate the development of dyslipidemia, liver steatosis and altered glucose homeostasis in offspring exposed to a sucrose-rich diet from utero to adulthood?

Prostaglandins Leukot Essent Fatty Acids. 2017 Jan;116:19-26. doi: 10.1016/j.plefa.2016.11.003. Epub 2016 Dec 6.


The present work analyzes the effects of dietary chia seeds during postnatal life in offspring exposed to a sucrose-rich diet (SRD) from utero to adulthood. At weaning, chia seed (rich in α-linolenic acid) replaced corn oil (rich in linoleic acid) in the SRD. At 150 days of offspring life, anthropometrical parameters, blood pressure, plasma metabolites, hepatic lipid metabolism and glucose homeostasis were analyzed. Results showed that chia was able to prevent the development of hypertension, liver steatosis, hypertriglyceridemia and hypercholesterolemia. Normal triacylglycerol secretion and triacylglycerol clearance were accompanied by an improvement of de novo hepatic lipogenic and carnitine-palmitoyl transferase-1 enzymatic activities, associated with an accretion of n-3 polyunsaturated fatty acids in the total composition of liver homogenate. Glucose homeostasis and plasma free fatty acid levels were improved while visceral adiposity was slightly decreased. These results confirm that the incorporation of chia seed in the diet in postnatal life may provide a viable therapeutic option for preventing/mitigating adverse outcomes induced by an SRD from utero to adulthood.

Keywords: Blood pressure; Chia-seed; Dyslipidemia; Glucose homeostasis; Liver steatosis; α-linolenic acid (ALA).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dietary Sucrose / adverse effects*
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / pharmacology
  • Dyslipidemias / prevention & control*
  • Edible Grain / chemistry
  • Fatty Acids, Nonesterified / blood
  • Fatty Liver / prevention & control*
  • Female
  • Glucose / metabolism
  • Homeostasis / drug effects
  • Pregnancy
  • Prenatal Exposure Delayed Effects / prevention & control*
  • Rats
  • Rats, Wistar
  • Salvia / chemistry*
  • Weaning
  • alpha-Linolenic Acid / administration & dosage*
  • alpha-Linolenic Acid / pharmacology


  • Dietary Sucrose
  • Drugs, Chinese Herbal
  • Fatty Acids, Nonesterified
  • alpha-Linolenic Acid
  • Glucose