Microparticles: Inflammatory and haemostatic biomarkers in Polycystic Ovary Syndrome

Mol Cell Endocrinol. 2017 Mar 5;443:155-162. doi: 10.1016/j.mce.2017.01.017. Epub 2017 Jan 11.

Abstract

Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women.

Keywords: Endothelial cells; Leukocytes; Microparticles; Platelets; Polycystic Ovary Syndrome; Tissue factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / metabolism*
  • Case-Control Studies
  • Cell-Derived Microparticles / metabolism*
  • Female
  • Hemostatics / metabolism*
  • Humans
  • Inflammation / pathology*
  • Polycystic Ovary Syndrome / metabolism*
  • Polycystic Ovary Syndrome / pathology*
  • Young Adult

Substances

  • Biomarkers
  • Hemostatics