The Lack of Association between FCN2 Gene Promoter Region Polymorphisms and Dental Caries in Polish Children

Caries Res. 2017;51(1):79-84. doi: 10.1159/000455054. Epub 2017 Jan 14.

Abstract

The aim of this study was to examine the association of single-nucleotide polymorphisms (SNPs) in the gene encoding ficolin-2 protein (FCN2 gene) at positions -986 (rs17514136), -602 (rs3124953), and -4 (rs3124952) with dental caries in Polish children. Two hundred and sixty Polish Caucasian children aged 15 years were enrolled in this study: 82 with "higher" caries experience (DMFT >5) and 178 with "lower" caries experience (DMFT ≤5). In addition, subjects with caries experience (DMFT ≥1) and caries-free subjects (DMFT = 0) were compared. FCN2 SNPs were genotyped with PCR-RFLP methods. There were no significant differences in the genotype, allele, or haplotype distributions in 3 analyzed SNPs of the FCN2 gene between children with "higher" and those with "lower" caries experience as well as between children with caries experience and caries-free children. In conclusion, we did not find any association of FCN2 promoter polymorphisms at positions -986, -602, and -4 with dental caries in Polish children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • DMF Index
  • Dental Caries / epidemiology*
  • Dental Caries / ethnology*
  • Dental Caries / genetics
  • Female
  • Ficolins
  • Gene Frequency
  • Genetic Predisposition to Disease / ethnology*
  • Genotyping Techniques
  • Haplotypes
  • Humans
  • Lectins / genetics*
  • Male
  • Poland / epidemiology
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic / genetics*

Substances

  • Lectins