Longitudinal association between hippocampus atrophy and episodic-memory decline

Neurobiol Aging. 2017 Mar;51:167-176. doi: 10.1016/j.neurobiolaging.2016.12.002. Epub 2016 Dec 11.


There is marked variability in both onset and rate of episodic-memory decline in aging. Structural magnetic resonance imaging studies have revealed that the extent of age-related brain changes varies markedly across individuals. Past studies of whether regional atrophy accounts for episodic-memory decline in aging have yielded inconclusive findings. Here we related 15-year changes in episodic memory to 4-year changes in cortical and subcortical gray matter volume and in white-matter connectivity and lesions. In addition, changes in word fluency, fluid IQ (Block Design), and processing speed were estimated and related to structural brain changes. Significant negative change over time was observed for all cognitive and brain measures. A robust brain-cognition change-change association was observed for episodic-memory decline and atrophy in the hippocampus. This association was significant for older (65-80 years) but not middle-aged (55-60 years) participants and not sensitive to the assumption of ignorable attrition. Thus, these longitudinal findings highlight medial-temporal lobe system integrity as particularly crucial for maintaining episodic-memory functioning in older age.

Keywords: Aging; Cognitive decline; Episodic memory; Hippocampus; Longitudinal changes; Nonignorable attrition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / pathology*
  • Aging / psychology*
  • Female
  • Hippocampus / diagnostic imaging
  • Hippocampus / pathology*
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders / diagnostic imaging
  • Memory Disorders / pathology*
  • Memory Disorders / psychology*
  • Memory, Episodic*
  • Middle Aged
  • Reaction Time
  • Time Factors