Reduced effects of age on dopamine D2 receptor levels in physically active adults

Neuroimage. 2017 Mar 1;148:123-129. doi: 10.1016/j.neuroimage.2017.01.018. Epub 2017 Jan 10.

Abstract

Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.

Keywords: Aging; Dopamine; Physical activity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Benzamides
  • Brain / diagnostic imaging
  • Brain / growth & development
  • Brain / physiology
  • Cross-Sectional Studies
  • Exercise / physiology*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Receptors, Dopamine D2 / metabolism
  • Receptors, Dopamine D2 / physiology*
  • Receptors, Dopamine D3 / metabolism
  • Young Adult

Substances

  • Benzamides
  • DRD2 protein, human
  • Radiopharmaceuticals
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • fallypride