Modes of Hypotensive Action of Dihydroquercetin in Arterial Hypertension

Bull Exp Biol Med. 2017 Jan;162(3):353-356. doi: 10.1007/s10517-017-3614-4. Epub 2017 Jan 14.

Abstract

We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change. In in vitro experiments, dihydroquercetin (10-8-10-6M) induced relaxation of the isolated thoracic aorta rings in a dose-dependent manner. Hence, the antihypertensive effect of dihydroquercetin results from the decrease in blood viscosity and vasodilation.

Keywords: SHR rats; arterial hypertension; dihydroquercetin; rheological indices; vascular tone of isolated preparation.

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Aorta, Thoracic / drug effects*
  • Aorta, Thoracic / physiopathology
  • Blood Pressure / drug effects
  • Dose-Response Relationship, Drug
  • Erythrocyte Aggregation / drug effects
  • Erythrocyte Deformability / drug effects
  • Gastric Absorption
  • Heart Ventricles / drug effects*
  • Heart Ventricles / physiopathology
  • Hematocrit
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Male
  • Quercetin / analogs & derivatives*
  • Quercetin / pharmacology
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Tissue Culture Techniques
  • Vasodilation / drug effects*
  • Viscosity / drug effects

Substances

  • Antihypertensive Agents
  • Quercetin
  • taxifolin