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Review
. 2018 Feb;55(2):1045-1053.
doi: 10.1007/s12035-016-0356-7. Epub 2017 Jan 14.

Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

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Review

Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

Lucineia Gainski Danielski et al. Mol Neurobiol. .

Abstract

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier's permeability is not only a cause but a consequence of brain injury in sepsis.

Keywords: Blood brain barrier; Blood-cerebrospinal fluid barrier; Microglial activation; Neuroinflammation; Sepsis.

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