Neural regulation of immunity: molecular mechanisms and clinical translation

Nat Neurosci. 2017 Feb;20(2):156-166. doi: 10.1038/nn.4477. Epub 2017 Jan 16.


Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Humans
  • Immunity / physiology*
  • Inflammation / immunology*
  • Nervous System Physiological Phenomena / immunology*
  • Neural Pathways / immunology*
  • Neurosciences / methods