Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies

J Matern Fetal Neonatal Med. 2018 Feb;31(3):271-277. doi: 10.1080/14767058.2017.1281906. Epub 2017 Feb 2.


Aim: The aim of this study was to discriminate mole pregnancies and invasive forms among cases with first trimester vaginal bleeding by the utilization of some complete blood count parameters conjunct to sonographic findings and beta human chorionic gonadotropin concentration.

Materials and methods: Consecutive 257 cases with histopathologically confirmed mole pregnancies and 199 women without mole pregnancy presented with first trimester vaginal bleeding who admitted to Zeynep Kamil Women and Children's Health Training Hospital between January 2012 and January 2016 were included in this cross-sectional study. The serum beta HCG level at presentation, and beta hCG levels at 1st, 2nd and 3rd weeks of postevacuation with some parameters of complete blood count were utilized to discriminate cases with molar pregnancy and cases with invasive mole among first trimester pregnants presented with vaginal bleeding and abnormal sonographic findings.

Results: Levels of beta hCG at baseline (AUC = 0.700, p < 0.05) and 1st (AUC = 0.704, p < 0.05), 2nd (AUC = 0.870, p < 0.001) and 3rd (AUC = 0.916, p < 0.001) weeks of postevacuation period were significant predictors for the cases with persistent disease. While area under curve for mean platelet volume is 0.715, it means that mean platelet volume has 21.5% additional diagnostic value for predicting persistency in molar patients. For 8.55 cut-off point for mean platelet volume, sensitivity is 84.6% and specificity is 51.6%. Area under curve for platelet/lymphocyte ratio is 0.683 means that platelet/lymphocyte ratio has additional 18.3% diagnostic value. For 102.25 cut-off point sensitivity is 86.6% and specificity is 46.2.

Conclusions: Simple, widely available complete blood count parameters may be used as an adjunct to other risk factors to diagnose molar pregnancies and predict postevacuation trophoblastic disease.

Keywords: Mole pregnancy; gestational trophoblastic disease; mean platelet volume; white blood cell count.

MeSH terms

  • Adult
  • Blood Cell Count
  • Case-Control Studies
  • Chorionic Gonadotropin, beta Subunit, Human / blood*
  • Female
  • Humans
  • Hydatidiform Mole, Invasive / blood*
  • Hydatidiform Mole, Invasive / complications
  • Hydatidiform Mole, Invasive / diagnostic imaging
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Trimester, First / blood
  • Ultrasonography
  • Uterine Hemorrhage / blood
  • Uterine Hemorrhage / etiology
  • Uterine Neoplasms / blood*
  • Uterine Neoplasms / complications
  • Uterine Neoplasms / diagnostic imaging
  • Young Adult


  • Chorionic Gonadotropin, beta Subunit, Human