Metabolomics and Metabolic Diseases: Where Do We Stand?

Cell Metab. 2017 Jan 10;25(1):43-56. doi: 10.1016/j.cmet.2016.09.018. Epub 2016 Oct 27.


Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, has undergone a rapid technological evolution in the past two decades. These advances have led to the application of metabolomics to defining predictive biomarkers for incident cardiometabolic diseases and, increasingly, as a blueprint for understanding those diseases' pathophysiologic mechanisms. Progress in this area and challenges for the future are reviewed here.

Keywords: cardiovascular diseases; diabetes; metabolic diseases; metabolism; metabolomics; obesity.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Metabolic Diseases / metabolism*
  • Metabolome
  • Metabolomics*
  • Models, Biological
  • Treatment Outcome