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Multicenter Study
. Feb-Mar 2017;69(2):229-237.
doi: 10.1080/01635581.2017.1265131. Epub 2017 Jan 17.

Plasma 25-Hydroxyvitamin D 3 Levels in Colorectal Cancer Patients and Associations With Physical Activity

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Free PMC article
Multicenter Study

Plasma 25-Hydroxyvitamin D 3 Levels in Colorectal Cancer Patients and Associations With Physical Activity

Stephanie Skender et al. Nutr Cancer. .
Free PMC article

Abstract

Physical activity (PA) and vitamin D are thought to affect colorectal cancer prognosis. The present study investigates associations between 25(OH)D3 and PA in prospectively followed colorectal cancer patients in the ColoCare study. At 6, 12, and 24 mo after surgery, patients donated a blood sample, wore an accelerometer for 10 consecutive days, and completed a PA questionnaire. Plasma 25-hydroxyvitamin D3 (25(OH)D3) levels were measured by high-performance liquid chromatography. We tested associations using partial correlations and multivariate linear regression analysis, adjusted for season, age, and body mass index. A total of 137 assessments of 25(OH)D3 levels and PA were conducted (58 at 6 mo, 51 at 12 mo, and 28 at 24 mo). More than 60% of the patients were vitamin D-deficient (25(OH)D3 ≤20 ng/ml), independent of study time point. At 6-mo follow-up, accelerometry-based vigorous and moderate-to-vigorous PAs were positively associated with 25(OH)D3 levels (P = 0.04; P = 0.006,). PA together with season was a significant predictor of elevated 25(OH)D3 levels. Our results suggest that the majority of colorectal cancer patients may suffer from vitamin D deficiency. Engaging in PA may be an effective approach to increase their 25(OH)D3 levels.

Conflict of interest statement

Conflict of interest:

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Description of 25(OH)D3 status by time points according to deficiency definitions by the American Geriatrics Society Workgroup on vitamin D supplementation
Figure 2
Figure 2
Differences in 25(OH)D3 levels by season at each time point

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