In silico prediction of Leishmania major-specific CD8 + epitopes

Exp Dermatol. 2017 Sep;26(9):838-840. doi: 10.1111/exd.13295. Epub 2017 Apr 20.

Abstract

Infections with Leishmania (L.) major induce protective IFN-γ-dependent Th1/Tc1 immunity in C57BL/6 mice as well as in immunocompetent humans. Even though antigen-specific immunity provides lifelong immunity against reinfection, a vaccine against this pathogen does not yet exist. Here, we compared the results obtained from in silico predictions of murine CD8-specific L. major peptides using the algorithm SYFPEITHI with the number and predicted affinity of known proteins/peptides. Our results indicate that the majority of "immunodominant" epitopes of L. major have not been identified so far; thus, computer-based prediction algorithms may aid the development of an effective vaccine.

Keywords: L. major; SYFPEITHI; epitope-prediction.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computer Simulation
  • Epitopes, T-Lymphocyte*
  • Leishmania major / immunology*
  • Leishmaniasis, Cutaneous / immunology*
  • Mice, Inbred C57BL

Substances

  • Epitopes, T-Lymphocyte