Nutrient sensing and TOR signaling in yeast and mammals

EMBO J. 2017 Feb 15;36(4):397-408. doi: 10.15252/embj.201696010. Epub 2017 Jan 17.


Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR-related diseases.

Keywords: RAG; TORC1; amino acids; glucose; mammals; nutrients; yeast.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Energy Metabolism
  • Food*
  • Mammals / physiology*
  • Saccharomyces cerevisiae / physiology*
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / metabolism*


  • TOR Serine-Threonine Kinases