Acute myelocytic leukemia and prior allergies

J Clin Epidemiol. 1989;42(10):995-1001. doi: 10.1016/0895-4356(89)90165-0.


The relationship between prior allergies and adult acute myelocytic leukemia was investigated in a population-based case-control study. Based on data from personal interviews of 98 cases and 133 controls, a history of any type of allergy was associated with a significantly decreased risk of acute myelocytic leukemia (OR = 0.35, 95% CI = 0.20-0.60). Risk declined with the total number of specific allergies reported (p less than 0.001), and was reduced in relation to a history of prior asthma, eczema and hives. The implications of these findings in relation to natural immune surveillance against developing neoplasms are discussed.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Humans
  • Hypersensitivity / complications*
  • Leukemia, Myeloid, Acute / epidemiology
  • Leukemia, Myeloid, Acute / etiology*
  • Male
  • Middle Aged
  • Odds Ratio
  • Registries
  • Risk
  • Washington / epidemiology