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, 7 (4), 169-174

Prevalence of Metabolic Syndrome in Pre- And Post-Menopausal Women: A Prospective Study From Apex Institute of North India


Prevalence of Metabolic Syndrome in Pre- And Post-Menopausal Women: A Prospective Study From Apex Institute of North India

Sandeep Sharma et al. J Midlife Health.


Background: The metabolic syndrome (MS) (syndrome X, insulin resistance syndrome) is a constellation of metabolic abnormalities and a complex predisease state that predicts future development of type 2 diabetes mellitus and cardiovascular disease. Menopausal transition and postmenopausal state are considered as a vulnerable period for developing MS, and this increased risk has been attributed to decreasing estrogen levels with an increasing risk of insulin resistance following menopause.

Aims and objectives: This study aimed to determine the prevalence of MS and its components in pre- and post-menopausal women from North India.

Methodology: This is a cross-sectional study of 350 women in the age group of 45-55 years attending gynecology clinic in a tertiary center of North India. Details of sociodemographic data, menopausal history, reproductive, and medical profile were obtained. Then, waist circumference, body mass index (BMI), and blood pressure were recorded. A venous blood sample was collected for fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. MS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III criteria.

Results: The mean age was 49.09 ± 2.2 years in premenopausal and 49.54 ± 2.8 years in postmenopausal women. The prevalence of MS in the study group was 62.6%. Occurrence of MS was higher in older and obese women. Abnormal waist circumference was the most prevalent component (87%) of MS and in terms of odd ratio, correlation was highest for BMI followed by total cholesterol and waist-hip ratio.

Conclusion: We should target obesity and deranged lipid profile by bringing out changes in lifestyle and dietary habits to decrease the higher prevalence of MS and the risk of cardiovascular diseases.

Keywords: Menopause; metabolic syndrome; postmenopausal women; premenopausal women.

Conflict of interest statement

There are no conflicts of interest.


Figure 1
Figure 1
The prevalence of individual variables of metabolic syndrome in both groups
Figure 2
Figure 2
Correlation of other components with metabolic syndrome

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