Rotating night shift work, sleep, and colorectal adenoma in women

Int J Colorectal Dis. 2017 Jul;32(7):1013-1018. doi: 10.1007/s00384-017-2758-z. Epub 2017 Jan 17.


Purpose: This study aims to investigate the associations of rotating night shift work history and sleep duration with risk of colorectal adenoma.

Methods: We evaluated 56,275 cancer-free participants of the Nurses' Health Study II, who had their first colonoscopy or sigmoidoscopy between 1991 and 2011; rotating night shift work and sleep duration were reported by mailed questionnaire. Multivariable-adjusted logistic regression was used to estimate relative risks (RR) of colorectal adenoma, with 95% confidence intervals (CI), across categories of rotating night shift work history (none, 1-4, 5-9, and ≥10 years) and sleep duration (≤5, 6, 7, 8, and ≥9 h/day).

Results: We found no association between duration of rotating night shift work and occurrence of colorectal adenoma (p-trend across shift work categories = 0.5). Women with the longest durations of rotating night shift work (≥10 years) had a similar risk of adenoma compared to women without a history of rotating night shift work (multivariable-adjusted RR = 0.96, 95% CI = 0.83-1.11). Similarly, there were no associations of shorter or longer sleep durations with adenoma risk (p-trend = 0.2 across sleep durations of ≤5 through 7 h/day and p-trend = 0.5 across sleep durations of 7 through ≥9 h/day). Results were similar when we examined associations according to adenoma location and subtype.

Conclusions: Our results do not support an association between rotating night shift work or sleep duration and risk of colorectal adenoma in women.

Keywords: Adenoma; Colonoscopy; Polyps; Rotating night shift work; Sleep; Women.

MeSH terms

  • Adenoma / epidemiology*
  • Adult
  • Colorectal Neoplasms / epidemiology*
  • Female
  • Humans
  • Middle Aged
  • Risk
  • Risk Factors
  • Shift Work Schedule / statistics & numerical data*
  • Sleep*