Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity

Antibiotics (Basel). 2017 Jan 13;6(1):2. doi: 10.3390/antibiotics6010002.


Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity.

Keywords: annulation; antibacterial; heteroaromatic; polyheterocycle; tetramate.