Experiments by in vitro screening test were made concerning many kinds of crude drugs, to determine anti-tumor activity in tissue cultured cell lines, such as human cancer cell (JTC-26) and a human normal embryonic cell (HE-1) lines. Consequently a group with high selective toxicity, in which the crude extracts of some traditional drugs inhibited the growth of the cancer cells in 500-120 micrograms/ml, but not normal cells, was shown.