Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity

Neuron. 2017 Jan 18;93(2):299-307. doi: 10.1016/j.neuron.2016.12.027.

Abstract

Background light intensity (irradiance) substantially impacts the visual code in the early visual system at synaptic and single-neuron levels, but its influence on population activity is largely unexplored. We show that fast narrowband oscillations, an important feature of population activity, systematically increase in amplitude as a function of irradiance in both anesthetized and awake, freely moving mice and at the level of the retina and dorsal lateral geniculate nucleus (dLGN). Narrowband coherence increases with irradiance across large areas of the dLGN, but especially for neighboring units. The spectral sensitivity of these effects and their substantial reduction in melanopsin knockout animals indicate a contribution from inner retinal photoreceptors. At bright backgrounds, narrowband coherence allows pooling of single-unit responses to become a viable strategy for enhancing visual signals within its frequency range.

Keywords: dorsal lateral geniculate nucleus; freely moving extracellular recordings; intrinsically photosensitive retinal ganglion cells; irradiance; melanopsin; metameric light stimuli; narrowband gamma oscillations; neural population coding; receptor silent substitution; retina.

MeSH terms

  • Animals
  • Electroretinography
  • Gamma Rhythm
  • Geniculate Bodies / physiology*
  • Light*
  • Mice
  • Mice, Knockout
  • Photic Stimulation
  • Retina / physiology*
  • Retinal Ganglion Cells / physiology*
  • Rod Opsins / genetics
  • Vision, Ocular / physiology*
  • Visual Pathways
  • Wakefulness

Substances

  • Rod Opsins
  • melanopsin