Translating Myocardial Remuscularization

Circ Res. 2017 Jan 20;120(2):278-281. doi: 10.1161/CIRCRESAHA.116.310194.


Myocardial re-muscularization can be achieved by implantation of cardiomyocyte-containing grafts. Critical steps towards clinical translation of the 1st generation cardiac re-muscularization therapies include the choice of animal models with high predictive validity for therapeutic outcome in clinical trials.

Keywords: heart failure; myocardium; regeneration; stem cells; tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Heart / physiology*
  • Humans
  • Myocardium / cytology
  • Myocytes, Cardiac / transplantation*
  • Regeneration / physiology
  • Stem Cell Transplantation / methods
  • Stem Cell Transplantation / trends*
  • Tissue Engineering / trends