Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants

J Hum Lact. 2017 Feb;33(1):181-187. doi: 10.1177/0890334416680176. Epub 2017 Jan 20.


Background: Mothers of preterm infants often are at risk of expressing an inadequate amount of milk for their infants and the use of galactogogues is often considered. Domperidone is a widely used galactogogue with little information available to guide clinicians regarding initiation, timing, and duration of treatment. Research aim: The primary objective of this study was to determine whether administration of domperidone within the first 21 days after delivery would lead to a higher proportion of mothers achieving a 50% increase in the volume of milk at the end of 14 days of treatment compared with mothers receiving placebo.

Methods: Eligible mothers were randomized to one of two treatment arms: Group A-domperidone 10 mg orally three times daily for 28 days; or Group B-placebo 10 mg orally three times daily for 14 days followed by domperidone 10 mg orally three times daily for 14 days.

Results: A total of 90 mothers of infants ≤ 29 weeks gestation were randomized. Mean milk volumes at entry were similar for both groups. More mothers achieved a 50% increase in milk volume after 14 days in Group A (77.8%) compared with Group B (57.8%), odds ratio = 2.56, 95% confidence interval [1.02, 6.25], p = .04.

Conclusion: A greater number of mothers experienced a 50% or more increase in human milk volume, but the absolute increase in milk volume was modest.

Keywords: breast milk expression; breastfeeding; galactogogues; human milk; human milk production; lactation difficulties; milk supply; randomized controlled trials.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Breast Feeding / methods*
  • Breast Feeding / statistics & numerical data
  • Domperidone / pharmacology
  • Domperidone / therapeutic use*
  • Female
  • Galactogogues / pharmacology
  • Galactogogues / therapeutic use
  • Humans
  • Infant, Newborn
  • Infant, Premature / metabolism
  • Lactation / drug effects*
  • Milk, Human / drug effects*
  • Mothers / statistics & numerical data


  • Galactogogues
  • Domperidone