Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials

Complement Ther Clin Pract. 2017 Feb;26:53-60. doi: 10.1016/j.ctcp.2016.11.008. Epub 2016 Nov 25.


Objective: To evaluate the effect of vitamin D supplementation on patients with PCOS.

Methods: We performed a literature search in database and identified all of the RCTs published before December 2015 that compared the effect of vitamin D supplementation with placebo or metformin in PCOS patients.

Main results: Nine out of 463 identified studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles (OR, 2.34; 95% CI, 1.39 to 3.92). Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone (OR, 1.85; 95% CI, 1.01 to 3.39).

Conclusions: Evidence from available RCTs suggests vitamin D supplementation may be beneficial for follicular development and menstrual cycle regulation in patients with PCOS. Additional high-quality RCTs are required to confirm the effectiveness of vitamin D on PCOS.

Keywords: Meta-analysis; PCOS; RCTs; Vitamin D.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Female
  • Humans
  • Polycystic Ovary Syndrome / drug therapy*
  • Randomized Controlled Trials as Topic
  • Vitamin D* / administration & dosage
  • Vitamin D* / therapeutic use


  • Vitamin D