Quality of sleep in renal transplant recipients and patients on hemodialysis

Paraskevi G Liaveri; Dimitris Dikeos; Ioannis Ilias; Eirini P Lygkoni; Ioannis N Boletis; Chryssanthi Skalioti; Thomas Paparrigopoulos

doi:10.1016/j.jpsychores.2016.12.013

Quality of sleep in renal transplant recipients and patients on hemodialysis

J Psychosom Res. 2017 Feb:93:96-101. doi: 10.1016/j.jpsychores.2016.12.013. Epub 2016 Dec 27.

Authors

Paraskevi G Liaveri¹, Dimitris Dikeos², Ioannis Ilias³, Eirini P Lygkoni⁴, Ioannis N Boletis⁵, Chryssanthi Skalioti⁵, Thomas Paparrigopoulos²

Affiliations

¹ Dialysis Unit, "Protypo Nefrologiko Kentro Attikis", Athens, Greece. Electronic address: paraskeviliaveri@yahoo.com.
² Sleep Research Unit, First Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, "Eginition" Hospital, Athens, Greece.
³ Endocrine Unit, "Elena Venizelou" Hospital, Athens, Greece.
⁴ School of Applied Mathematics and Physical Science, National Technical University of Athens, Athens, Greece.
⁵ Nephrology Department, Renal Transplantation Unit, "Laikon" Hospital, Athens, Greece.

PMID: 28107900
DOI: 10.1016/j.jpsychores.2016.12.013

Abstract

Background: Sleep disorders are very common in patients with chronic kidney disease and they may not always subside after kidney transplantation.

Aim and methods: The aim of this cross-sectional study was to evaluate the self-reported quality of sleep, insomnia problems in particular, and examine the factors that disturb sleep of kidney transplant recipients (KTx: n=152) in comparison to age- and sex-matched patients on dialysis (HD: n=67) and participants with normal renal function (NOR: n=49), through the administration of the Athens Insomnia Scale (AIS) at least six months after transplantation. Clinical and laboratory data, as well as health-related quality of life, depression, anxiety, post-traumatic stress symptoms, and the presence of restless legs syndrome (RLS) and pruritus were investigated in relation to sleep problems.

Results: The highest mean AIS score was observed in the transplant patients (KTx: 4.6±13.3 vs. HD: 3.8±8.1 vs. NOR: 2.4±10.2); both KTx and HD patients had a lower quality of sleep compared to participants with normal renal function. Multiple linear regression analysis showed that the determinants of the total AIS score were the frequency of post-traumatic stress symptoms, depression, RLS, diastolic blood pressure, and pain (all p<0.0001).

Conclusion: Although amelioration of renal function post-transplantation improves several aspects of quality of life, it does not seem to have a beneficial effect on self-reported sleep.

Keywords: Blood pressure; Hemodialysis; PTSD; Renal transplantation; Sleep quality.

MeSH terms

Adult
Cross-Sectional Studies
Female
Humans
Kidney Failure, Chronic / psychology*
Kidney Failure, Chronic / therapy*
Kidney Transplantation / psychology*
Male
Middle Aged
Postoperative Complications / diagnosis*
Postoperative Complications / psychology*
Quality of Life / psychology
Renal Dialysis
Restless Legs Syndrome / diagnosis
Restless Legs Syndrome / psychology
Sleep Initiation and Maintenance Disorders / diagnosis
Sleep Initiation and Maintenance Disorders / psychology*
Surveys and Questionnaires