TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

Alan C Mullen; Jeffrey L Wrana

doi:10.1101/cshperspect.a022186

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):a022186. doi: 10.1101/cshperspect.a022186.

Authors

Alan C Mullen^{1

2}, Jeffrey L Wrana³

Affiliations

¹ Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.
² Harvard Stem Cell Institute, Cambridge, Massachusetts 02138.
³ Lunenfeld-Tanenbam Research Institute, Mount Sinai Hospital and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X5, Canada.

Abstract

Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate and invertebrate models revealed the TGF-β family to be central regulators of tissue morphogenesis. Members of the TGF-β family direct some of the earliest cell-fate decisions in animal development, coordinate complex organogenesis, and contribute to tissue homeostasis in the adult. Here, we focus on the role of the TGF-β family in mammalian stem-cell biology and discuss its wide and varied activities both in the regulation of pluripotency and in cell-fate commitment.

Publication types

Review

MeSH terms

Adult Stem Cells / cytology
Adult Stem Cells / metabolism*
Animals
Bone Morphogenetic Proteins / metabolism
Bone Morphogenetic Proteins / physiology
Cell Differentiation*
Cell Self Renewal*
Embryonic Stem Cells / cytology
Embryonic Stem Cells / metabolism*
Gene Expression Regulation, Developmental
Humans
Mice
Signal Transduction
Transforming Growth Factor beta / metabolism*

Substances

Bone Morphogenetic Proteins
Transforming Growth Factor beta

Abstract

Publication types

MeSH terms

Substances

Grants and funding