Serum insulin in pathogenesis and treatment of osteoarthritis

Med Hypotheses. 2017 Feb;99:45-46. doi: 10.1016/j.mehy.2016.12.010. Epub 2016 Dec 23.

Abstract

Osteoarthritis (OA) is one of the major health problems that's development and progression is obesity-related. We believe that higher levels of insulin may explains this link especially. High levels of insulin in obesity and metabolic syndrome can induce numerous complications. Insulin can increase proliferation of chondrocyte but simultaneously, it prevents their differentiation. Moreover, hyperinsulinemia reduces the circulating level of serum T4 and conversion of T4 to T3, mimicking hypothyroidism, because thyroid hormones are necessary for the maturation of chondrocytes. So maybe decreasing insulin levels, prevents OA progression or improve the treatment process.

Keywords: Adiponectins; Insulin; Metabolic syndrome; Osteoarthritis.

MeSH terms

  • Adipokines / metabolism
  • Cartilage / metabolism
  • Cell Differentiation
  • Cell Proliferation
  • Chondrocytes / cytology
  • Disease Progression
  • Homeostasis
  • Humans
  • Hyperinsulinism / metabolism
  • Hypothyroidism / metabolism
  • Inflammation
  • Insulin / blood*
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / complications
  • Models, Theoretical
  • Obesity / blood
  • Obesity / complications
  • Osteoarthritis / blood*
  • Osteoarthritis / physiopathology*
  • Osteoarthritis / therapy*
  • Thyroxine / metabolism
  • Triiodothyronine / metabolism

Substances

  • Adipokines
  • Insulin
  • Triiodothyronine
  • Thyroxine