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. 2017 Feb 24;80(2):565-568.
doi: 10.1021/acs.jnatprod.6b00935. Epub 2017 Jan 23.

Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029T

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Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029T

Shoko Hara et al. J Nat Prod. .

Abstract

Two new aminocyclitol amide derivatives, nabscessins A (1) and B (2), were isolated from the culture broth of a pathogenic actinomycete species, Nocardia abscessus IFM 10029T. The structures of nabscessins A and B were elucidated by spectral studies, and the compounds showed antifungal activity against Cryptococcus neoformans, with IC50 values of 32 and 16 μg/mL, respectively.

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