Lead Adsorption, Anticoagulation and in Vivo Toxicity Studies on the New Magnetic Nanomaterial Fe 3 O 4@SiO 2@DMSA as a Hemoperfusion Adsorbent

Nanomedicine. 2017 May;13(4):1341-1351. doi: 10.1016/j.nano.2017.01.007. Epub 2017 Jan 20.

Abstract

This project aimed to develop and characterize a new nanoadsorbent for hemoperfusion. Fe3O4 nanoparticles synthesized by a facile solvothermal method were coated with SiO2 and further modified by DMSA. TEM, XRD, FTIR, XPS and SEM were performed before and after lead adsorption to reveal the general performance and adsorption mechanism. Rabbit lead poisoning models were established to study the adsorption rate; then, a pig hemoperfusion experiment was used for further validation. In addition, coagulation, liver, kidney and heart function, blood lipids, electrolytes and the immune inflammatory system were studied before and after hemoperfusion. The results indicated that the materials had a high adsorption rate and chemisorbed lead mainly in the plasma. No obvious coagulation-fibrinolysis, organ toxicity, electrolyte disturbances, inflammatory reactions or immunosuppression was observed. The excellent blood compatibility and high biosafety of this material demonstrate its potential as a new type of hemoperfusion adsorbent.

Keywords: Adsorption mechanism; Biosafety; Fe(3)O(4)@SiO(2)@DMSA nanoparticle; Hemoperfusion; Pigs.

MeSH terms

  • Adsorption
  • Animals
  • Ferrosoferric Oxide / chemistry*
  • Hemoperfusion*
  • Lead / chemistry*
  • Lead Poisoning / therapy*
  • Materials Testing
  • Nanoparticles / chemistry*
  • Rabbits
  • Silicon Dioxide / chemistry
  • Succimer / chemistry
  • Swine
  • Toxicity Tests

Substances

  • Lead
  • Silicon Dioxide
  • Succimer
  • Ferrosoferric Oxide