Infection: the neglected paradigm in SIDS research

Arch Dis Child. 2017 Aug;102(8):767-772. doi: 10.1136/archdischild-2016-312327. Epub 2017 Jan 23.

Abstract

Despite decades of investigation and millions of dollars spent, the cause of sudden infant death syndrome (SIDS) eludes researchers. It is timely therefore to reconsider the reasons for this failure and to explore how research might go forward with better prospects. This review assesses SIDS research in the context of clinicopathological and epidemiological features and determines that only infection attains congruence.

Keywords: Epidemiology; Infectious Diseases; Pathology; SIDS.

Publication types

  • Review

MeSH terms

  • Autopsy
  • Biomarkers / metabolism
  • Biomedical Research / trends*
  • Blood Coagulation Disorders / complications
  • Female
  • Gastrointestinal Microbiome / physiology
  • Humans
  • Infant
  • Infant Care
  • Infections*
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Risk Factors
  • Sex Factors
  • Sudden Infant Death / etiology*
  • Sudden Infant Death / pathology

Substances

  • Biomarkers