Testosterone Deficiency and Sleep Apnea

Sleep Med Clin. 2016 Dec;11(4):525-529. doi: 10.1016/j.jsmc.2016.08.003. Epub 2016 Oct 27.


Obstructive sleep apnea (OSA) is a common condition among middle-aged men and is often associated with reduced testosterone (T) levels. OSA can contribute to fatigue and sexual dysfunction in men. There is suggestion that T supplementation alters ventilatory responses, possibly through effects on central chemoreceptors. Traditionally, it has been recommended that T replacement therapy (TRT) be avoided in the presence of untreated severe sleep apnea. With OSA treatment, however, TRT may not only improve hypogonadism, but may also alleviate erectile/sexual dysfunction.

Keywords: Continuous positive airway pressure; Obstructive sleep apnea; Sexual dysfunction; Testosterone deficiency.

Publication types

  • Review

MeSH terms

  • Humans
  • Male
  • Sleep Apnea Syndromes / blood*
  • Testosterone / blood*
  • Testosterone / deficiency*


  • Testosterone