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Lung Regeneration Therapy for Chronic Obstructive Pulmonary Disease


Lung Regeneration Therapy for Chronic Obstructive Pulmonary Disease

Dong Kyu Oh et al. Tuberc Respir Dis (Seoul).


Chronic obstructive pulmonary disease (COPD) is a critical condition with high morbidity and mortality. Although several medications are available, there are no definite treatments. However, recent advances in the understanding of stem and progenitor cells in the lung, and molecular changes during re-alveolization after pneumonectomy, have made it possible to envisage the regeneration of damaged lungs. With this background, numerous studies of stem cells and various stimulatory molecules have been undertaken, to try and regenerate destroyed lungs in animal models of COPD. Both the cell and drug therapies show promising results. However, in contrast to the successes in laboratories, no clinical trials have exhibited satisfactory efficacy, although they were generally safe and tolerable. In this article, we review the previous experimental and clinical trials, and summarize the recent advances in lung regeneration therapy for COPD. Furthermore, we discuss the current limitations and future perspectives of this emerging field.

Keywords: Cell- and Tissue-Based Therapy; Drug Therapy; Emphysema; Lung; Pulmonary Disease, Chronic Obstructive; Regeneration; Regenerative Medicine; Retinoids; Stem Cells.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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    1. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease [Internet] Global Initiative for Chronic Obstructive Lung Disease; 2015. [cited 2015 Dec 21]. Available from:
    1. Kotton DN, Morrisey EE. Lung regeneration: mechanisms, applications and emerging stem cell populations. Nat Med. 2014;20:822–832. - PMC - PubMed
    1. Rock J, Konigshoff M. Endogenous lung regeneration: potential and limitations. Am J Respir Crit Care Med. 2012;186:1213–1219. - PubMed
    1. Adamson IY, Bowden DH. Derivation of type 1 epithelium from type 2 cells in the developing rat lung. Lab Invest. 1975;32:736–745. - PubMed
    1. Voss GJ, Kump DK, Walker JA, Voss SR. Variation in salamander tail regeneration is associated with genetic factors that determine tail morphology. PLoS One. 2013;8:e67274. - PMC - PubMed