Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans

Nature. 1989 Nov 2;342(6245):45-50. doi: 10.1038/342045a0.


The Caenorhabditis elegans gene unc-22 encodes a very large muscle protein, called twitchin, which consists of a protein kinase domain and several copies of two short motifs. The sequence of twitchin has unexpected similarities to the sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules and vertebrate muscle proteins, including myosin light-chain kinase. These homologies, together with results from earlier genetic and molecular analyses, indicate that twitchin is involved in a novel mechanism of myosin regulation.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis / genetics*
  • Caenorhabditis / metabolism
  • Caenorhabditis elegans Proteins*
  • Calmodulin-Binding Proteins*
  • Genes
  • Helminth Proteins / genetics*
  • Molecular Sequence Data
  • Muscle Proteins / genetics*
  • Myosin-Light-Chain Kinase / genetics
  • Myosins / metabolism*
  • Protein Kinases / genetics*
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid


  • Caenorhabditis elegans Proteins
  • Calmodulin-Binding Proteins
  • Helminth Proteins
  • Muscle Proteins
  • unc-22 protein, C elegans
  • Protein Kinases
  • Myosin-Light-Chain Kinase
  • Myosins