Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps

Microcirculation. 2017 Apr;24(3):10.1111/micc.12352. doi: 10.1111/micc.12352.


Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium cross talk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.

Keywords: endothelial barrier dysfunction; neutrophil extracellular traps; vascular hyperpermeability.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Endothelium, Vascular / injuries*
  • Extracellular Traps / physiology*
  • Humans
  • Microcirculation
  • Neutrophil Activation*
  • Neutrophils / physiology*
  • Receptor Cross-Talk
  • Signal Transduction