Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Mar;272:68-71.
doi: 10.1016/j.forsciint.2017.01.008. Epub 2017 Jan 16.

Topical Application of THC Containing Products Is Not Able to Cause Positive Cannabinoid Finding in Blood or Urine

Affiliations
Case Reports

Topical Application of THC Containing Products Is Not Able to Cause Positive Cannabinoid Finding in Blood or Urine

C Hess et al. Forensic Sci Int. .

Abstract

A male driver was checked during a traffic stop. A blood sample was collected 35min later and contained 7.3ng/mL THC, 3.5ng/mL 11-hydroxy-THC and 44.6ng/mL 11-nor-9-carboxy-THC. The subject claimed to have used two commercially produced products topically that contained 1.7ng and 102ng THC per mg, respectively. In an experiment, three volunteers (25, 26 and 34 years) applied both types of salves over a period of 3days every 2-4h. The application was extensive (50-100cm2). Each volunteer applied the products to different parts of the body (neck, arm/leg and trunk, respectively). After the first application blood and urine samples of the participants were taken every 2-4h until 15h after the last application (overall n=10 urine and n=10 blood samples, respectively, for each participant). All of these blood and urine samples were tested negative for THC, 11-hydroxy-THC and 11-nor-9-carboxy-THC by a GC-MS method (LoD (THC)=0.40ng/mL; LoD (11-hydroxy-THC)=0.28ng/mL; LoD (THC-COOH)=1.6ng/mL;. LoD (THC-COOH in urine)=1.2ng/mL). According to our studies and further literature research on in vitro testing of transdermal uptake of THC, the exclusive application of (these two) topically applied products did not produce cannabinoid findings in blood or urine.

Keywords: Cannabinoids; Gaschromatography mass spectrometry; Hemp oil containing cremes; Topic.

Similar articles

See all similar articles

Publication types

LinkOut - more resources

Feedback