Treatment of cefuroxime-induced neurotoxicity with continuous venovenous haemofiltration

Neth J Med. 2017 Jan;75(1):32-34.


A 61-year-old woman with decreased consciousness, myoclonus, tremors, nystagmus and bradypnoea, due to cefuroxime-induced neurotoxicity, was admitted to the intensive care unit. Continuous venovenous haemofiltration (CVVH) rapidly reduced plasma cefuroxime concentrations and improved neurological manifestations within the next few hours. Retrospective pharmacokinetic assessment showed a total cefuroxime clearance of 166 ml/min during the CVVH.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / blood
  • Cefuroxime / adverse effects*
  • Cefuroxime / blood
  • Female
  • Hemofiltration / methods*
  • Humans
  • Intensive Care Units
  • Middle Aged
  • Neurotoxicity Syndromes / etiology
  • Neurotoxicity Syndromes / therapy*
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Cefuroxime