Role of Rab GTPases in the export trafficking of G protein-coupled receptors

Small GTPases. 2018 Mar 4;9(1-2):130-135. doi: 10.1080/21541248.2016.1277000. Epub 2017 Jan 27.


G protein-coupled receptors (GPCRs) constitute a superfamily of cell surface receptors that regulate a variety of cell functions. As the cell surface is the functional destination for most GPCRs, the cell surface targeting process represents a crucial checkpoint in controlling the functionality of the receptors. However, the molecular mechanisms underlying the cell surface delivery of newly synthesized GPCRs remain poorly understood. In this review, we will highlight the role of Rab GTPases in GPCR cell surface transport, particularly post-Golgi traffic, and discuss the underlying molecular mechanisms.

Keywords: G protein-coupled receptor; Rab GTPase; Rab26; Rab8; cell surface expression; export trafficking; post-Golgi traffic.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Protein Transport
  • Receptors, G-Protein-Coupled / metabolism*
  • Substrate Specificity
  • rab GTP-Binding Proteins / metabolism*


  • Receptors, G-Protein-Coupled
  • rab GTP-Binding Proteins