Converse motor output of inspiratory bulbospinal premotoneurones during vomiting

Neurosci Lett. 1989 Oct 9;104(3):298-302. doi: 10.1016/0304-3940(89)90592-2.

Abstract

Intracellular recordings of the activities of 10 inspiratory bulbospinal neurones of the medulla were performed in decerebrate cats. Fictive vomiting was induced by repetitive stimulation of the supra-diaphragmatic vagus nerves and was defined by series of synchronous large bursts in both the phrenic (inspiratory) and abdominal (expiratory) nerves. During these synchronous bursts the inspiratory bulbospinal neurones of both the dorsal and ventral respiratory groups were strongly hyperpolarized by chloride-dependent inhibitory postsynaptic potentials (IPSPs). We concluded that during vomiting the central pattern generator is inhibited, and that another pattern generator drives the spinal respiratory motoneurones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Cats
  • Ganglia, Spinal / physiopathology*
  • Medulla Oblongata / physiopathology*
  • Membrane Potentials
  • Motor Neurons / physiology*
  • Vomiting / physiopathology*