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Editorial
. 2017 Mar;21(3):235-237.
doi: 10.1080/14728222.2017.1287899.

Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder

Kyle A Lyman  1 , Ye Han  1 , Dane M Chetkovich  1
Affiliations
Editorial

Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder

Kyle A Lyman et al. Expert Opin Ther Targets. 2017 Mar.
No abstract available

Keywords: HCN; Pex5; TRIP8b; depression; ion channel.

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Conflict of interest statement

Declaration of Interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1
Figure 1
Schematic of the interaction between HCN and TRIP8b, reproduced from our previous report. A single subunit of HCN is represented in black, with the cyclic-nucleotide binding domain (CNBD) and C terminal tail (SNL) highlighted. TRIP8b contains a variable N terminus (in green) as well as a domain that interacts with the CNBD (represented by a red shape) and a series of TPR domains (gray shapes) that interact with the C terminus of HCN.
See this image and copyright information in PMC

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