Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora

J Nat Prod. 2017 Mar 24;80(3):707-712. doi: 10.1021/acs.jnatprod.6b01091. Epub 2017 Jan 27.

Abstract

Studies of the genome-sequenced, flutimide-producing coprophilous fungus Delitschia confertaspora (ATCC 74209), originally obtained from a sample of rock hyrax (Procavia capensis) dung collected in Namibia, led to the discovery of three new highly aromatic natural products named delicoferones A-B (1-2) and fimetarone B (3). The new benzophenone derivatives 1 and 2 have a somewhat unusual skeleton that incorporates three aromatic rings linked via two ketone carbonyl groups, while 3 contains a spiro[chroman-3,7'-isochromene]-4,6'(8'H) skeleton reported only once previously. The structures of these compounds were assigned mainly by analysis of 2D NMR and HRESITOFMS data.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Benzophenones / chemistry
  • Benzophenones / isolation & purification*
  • Fungi / chemistry*
  • Hyraxes
  • Molecular Structure
  • Namibia
  • Nuclear Magnetic Resonance, Biomolecular
  • Spiro Compounds / chemistry
  • Spiro Compounds / isolation & purification*

Substances

  • Benzophenones
  • Spiro Compounds
  • delicoferone A
  • delicoferone B
  • fimetarone A