Chemical screening in zebrafish for novel biological and therapeutic discovery

Methods Cell Biol. 2017;138:651-679. doi: 10.1016/bs.mcb.2016.10.004. Epub 2016 Dec 29.

Abstract

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.

Keywords: Chemical; Chemoinformatic; Hit; Libraries; Phenotype; Screen; Zebrafish.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Discovery / methods*
  • Drug Evaluation, Preclinical / methods*
  • Embryo, Nonmammalian / drug effects
  • High-Throughput Screening Assays / methods*
  • Humans
  • Small Molecule Libraries / pharmacology
  • Zebrafish / genetics
  • Zebrafish / growth & development*

Substances

  • Small Molecule Libraries