Renoprotective chemical constituents from an edible mushroom, Pleurotus cornucopiae in cisplatin-induced nephrotoxicity
- PMID: 28129885
- DOI: 10.1016/j.bioorg.2017.01.012
Renoprotective chemical constituents from an edible mushroom, Pleurotus cornucopiae in cisplatin-induced nephrotoxicity
Abstract
Pleurotus cornucopiae (Pleurotaceae) is an edible and medicinal mushroom widely distributed in Korea, China, and Japan. The MeOH extract of the fruiting bodies of P. cornucopiae showed renoprotective effects against cisplatin-induced kidney cell damage. Chemical investigation of the MeOH extract led to the isolation and identification of 12 compounds including noransine (1), uridine (2), uracil (3), (3β, 5α, 6β, 22E, 24S) -ergosta-7, 22-diene-3, 5, 6, 9-tetrol (4), (22E,24S)-ergosta-7,22-diene-3β,5α,6β-triol (5), (22E,24R)-ergosta-8(14),22-diene-3β,5α,6β,7α-tetrol (6), cerebroside B (7), (2R) -N- [(1S, 2R, 3E, 7E) -1- [(β-d-glucopyranosyloxy) methyl] -2-hydroxy-8-methyl-3, 7-heptadecadien-1-yl] -2-hydroxy-heptadecanamide (8), cerebroside D (9), nicotinamide (10), 1,2-bis(hydroxymethyl)-4,5-dimethoxybenzene (11), and benzoic acid (12). Among them, compounds 1 and 11 were isolated as naturally occurring products for the first time, though they were reported as synthetic products in previous papers. All of the compounds (except 8 and 11) abrogated cisplatin-induced LLC-PK1 cell damage in a dose-dependent manner. Of special note, compounds 2, 5, 6, and 12 ameliorated cisplatin-induced nephrotoxicity to 80% of the control value at 10μM. The protective effects of compounds 2, 5, 6, and 12 were mediated via the deactivation of JNK-caspase 3 apoptotic cascade. This study is the first to demonstrate that the chemical constituents of P. cornucopiae display renoprotective effects against anticancer drug-induced damage in kidney cells.
Keywords: MAPKs; Mushroom; Nephrotoxicity; Pleurotaceae; Pleurotus cornucopiae.
Copyright © 2017 Elsevier Inc. All rights reserved.
Similar articles
-
C28 steroids from the fruiting bodies of Ganoderma resinaceum with potential anti-inflammatory activity.Phytochemistry. 2019 Dec;168:112109. doi: 10.1016/j.phytochem.2019.112109. Epub 2019 Sep 5. Phytochemistry. 2019. PMID: 31494344
-
Steroids and phenolic constituents from the fruiting bodies of the basidiomycete Sarcodon joedes.Nat Prod Res. 2013;27(1):80-4. doi: 10.1080/14786419.2012.656112. Epub 2012 Feb 9. Nat Prod Res. 2013. PMID: 22320163
-
Six new ergostane-type steroids from king trumpet mushroom (Pleurotus eryngii) and their inhibitory effects on nitric oxide production.Steroids. 2016 Nov;115:9-17. doi: 10.1016/j.steroids.2016.07.005. Epub 2016 Jul 14. Steroids. 2016. PMID: 27423395
-
Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity.Mini Rev Med Chem. 2019;19(14):1134-1143. doi: 10.2174/1389557519666190320124438. Mini Rev Med Chem. 2019. PMID: 30894108 Review.
-
Ergosterol Peroxide: A Mushroom-Derived Compound with Promising Biological Activities-A Review.Int J Med Mushrooms. 2017;19(2):93-105. doi: 10.1615/IntJMedMushrooms.v19.i2.10. Int J Med Mushrooms. 2017. PMID: 28436318 Review.
Cited by
-
Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products.Biomolecules. 2022 Aug 5;12(8):1078. doi: 10.3390/biom12081078. Biomolecules. 2022. PMID: 36008971 Free PMC article. Review.
-
Estrogenic Activity of Mycoestrogen (3β,5α,22E)-Ergost-22-en-3-ol via Estrogen Receptor α-Dependent Signaling Pathways in MCF-7 Cells.Molecules. 2021 Dec 22;27(1):36. doi: 10.3390/molecules27010036. Molecules. 2021. PMID: 35011267 Free PMC article.
-
1H-NMR Metabolomic Study of the Mushroom Pleurotus djamor for the Identification of Nematocidal Compounds.Pharmaceuticals (Basel). 2024 Apr 30;17(5):580. doi: 10.3390/ph17050580. Pharmaceuticals (Basel). 2024. PMID: 38794150 Free PMC article.
-
Anti-Inflammatory Phenolic Metabolites from the Edible Fungus Phellinus baumii in LPS-Stimulated RAW264.7 Cells.Molecules. 2017 Sep 21;22(10):1583. doi: 10.3390/molecules22101583. Molecules. 2017. PMID: 28934155 Free PMC article.
-
Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity.J Fungi (Basel). 2022 Sep 24;8(10):1002. doi: 10.3390/jof8101002. J Fungi (Basel). 2022. PMID: 36294567 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
