Hedgehog Signaling Inhibitors Fail to Reduce Merkel Cell Carcinoma Viability

J Invest Dermatol. 2017 May;137(5):1187-1190. doi: 10.1016/j.jid.2017.01.008. Epub 2017 Jan 25.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • Anilides / therapeutic use
  • Biopsy
  • Carcinoma, Merkel Cell / drug therapy
  • Carcinoma, Merkel Cell / metabolism*
  • Carcinoma, Merkel Cell / pathology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Fatal Outcome
  • Gene Expression Regulation, Neoplastic*
  • Hedgehog Proteins / antagonists & inhibitors*
  • Hedgehog Proteins / metabolism
  • Humans
  • Male
  • Oligonucleotide Array Sequence Analysis
  • Pyridines / therapeutic use
  • Signal Transduction
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Tomography, X-Ray Computed

Substances

  • Anilides
  • Hedgehog Proteins
  • HhAntag691
  • Pyridines