Cholesterol, lipoproteins and subclinical interstitial lung disease: the MESA study

Thorax. 2017 May;72(5):472-474. doi: 10.1136/thoraxjnl-2016-209568. Epub 2017 Jan 27.

Abstract

We investigated associations of plasma lipoproteins with subclinical interstitial lung disease (ILD) by measuring high attenuation areas (HAA: lung voxels between -600 and -250 Hounsfield units) in 6700 adults and serum MMP-7 and SP-A in 1216 adults age 45-84 without clinical cardiovascular disease in Multi-Ethnic Study of Atherosclerosis. In cross-sectional analyses, each SD decrement in high density lipoprotein cholesterol (HDL-C) was associated with a 2.12% HAA increment (95% CI 1.44% to 2.79%), a 3.53% MMP-7 increment (95% CI 0.93% to 6.07%) and a 6.37% SP-A increment (95% CI 1.35% to 11.13%), independent of demographics, smoking and inflammatory biomarkers. These findings support a novel hypothesis that HDL-C might influence subclinical lung injury and extracellular matrix remodelling.

Keywords: Clinical Epidemiology; Idiopathic pulmonary fibrosis; Imaging/CT MRI etc; Interstitial Fibrosis.

Publication types

  • Letter
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Cholesterol, HDL / blood
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnostic imaging
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lipoproteins / blood*
  • Lung Diseases, Interstitial / blood*
  • Lung Diseases, Interstitial / diagnostic imaging
  • Male
  • Matrix Metalloproteinase 7 / blood
  • Middle Aged
  • Prospective Studies
  • Pulmonary Surfactant-Associated Protein A / blood*
  • Tomography, X-Ray Computed

Substances

  • Biomarkers
  • Cholesterol, HDL
  • Lipoproteins
  • Pulmonary Surfactant-Associated Protein A
  • Matrix Metalloproteinase 7