Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Mar;67(2):283-301.
doi: 10.1007/s12576-017-0521-4. Epub 2017 Jan 27.

Physiological Roles of Zinc Transporters: Molecular and Genetic Importance in Zinc Homeostasis


Physiological Roles of Zinc Transporters: Molecular and Genetic Importance in Zinc Homeostasis

Takafumi Hara et al. J Physiol Sci. .


Zinc (Zn) is an essential trace mineral that regulates the expression and activation of biological molecules such as transcription factors, enzymes, adapters, channels, and growth factors, along with their receptors. Zn deficiency or excessive Zn absorption disrupts Zn homeostasis and affects growth, morphogenesis, and immune response, as well as neurosensory and endocrine functions. Zn levels must be adjusted properly to maintain the cellular processes and biological responses necessary for life. Zn transporters regulate Zn levels by controlling Zn influx and efflux between extracellular and intracellular compartments, thus, modulating the Zn concentration and distribution. Although the physiological functions of the Zn transporters remain to be clarified, there is growing evidence that Zn transporters are related to human diseases, and that Zn transporter-mediated Zn ion acts as a signaling factor, called "Zinc signal". Here we describe critical roles of Zn transporters in the body and their contribution at the molecular, biochemical, and genetic levels, and review recently reported disease-related mutations in the Zn transporter genes.

Keywords: Disease; Physiology; Transporter; Zinc; Zinc signaling.

Similar articles

See all similar articles

Cited by 44 articles

See all "Cited by" articles


    1. Hum Mol Genet. 2002 Jul 15;11(15):1775-84 - PubMed
    1. Prog Neurobiol. 2011 Mar;93(3):405-20 - PubMed
    1. J Physiol Sci. 2017 Jul;67(4):497-505 - PubMed
    1. Mol Hum Reprod. 2014 Nov;20(11):1077-89 - PubMed
    1. Proc Natl Acad Sci U S A. 2005 May 10;102(19):6843-8 - PubMed

LinkOut - more resources