The Effects of Bariatric Surgery on Bone Metabolism

Endocrinol Metab Clin North Am. 2017 Mar;46(1):105-116. doi: 10.1016/j.ecl.2016.09.011. Epub 2016 Nov 25.

Abstract

Most metabolic effects following bariatric surgery are favorable. One area in which the consequences seem to be detrimental is on skeletal health. Mechanisms that have been cited include malabsorption of calcium and vitamin D, decrease in mechanical loading, and changes in gastrointestinal and fat-derived hormone levels. It is important that the impact of these procedures on bone metabolism is closely examined. The significance of the bone loss that occurs, and its possible effect on future fracture risk, should also be evaluated.

Keywords: Adipokines; Bariatric surgery; Bone turnover markers; DXA; Gut hormones; Obesity.

Publication types

  • Review

MeSH terms

  • Bariatric Surgery / adverse effects*
  • Bone and Bones / physiology*
  • Calcium, Dietary / metabolism
  • Fractures, Bone / complications
  • Hormones / physiology
  • Humans
  • Obesity, Morbid / surgery
  • Vitamin D / metabolism
  • Weight Loss
  • Weight-Bearing

Substances

  • Calcium, Dietary
  • Hormones
  • Vitamin D